polatuzumab vedotin-piiq for injection
polatuzumab vedotin-piiq for injection,
for intravenous use Initial U.S. Approval: 2019
Polivy (polatuzumab vedotin-piiq) is a medication indicated in combination with bendamustine and a rituximab product for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma, not otherwise specified, after at least two prior therapies. Diffuse large B-cell lymphoma is a type of non-Hodgkin lymphoma.
Facts about polatuzumab vedotin-piiq for injection
Disease Indications-Lymphoma
Manufacturer-Genentech, Inc
Usage-Intravenous
Medicine Approved By-Food and Drug Administration (FDA), Pharmaceuticals and Medical Devices Agency (PMDA), Therapeutic Goods Administration (TGA)
Summary of FDA-approved use on approval date: Click Here
(see Drugs@FDA for complete indication)
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Query For polatuzumab vedotin-piiq for injection
Approved accessible "polatuzumab vedotin-piiq for injection"
On April 19, 2023, the Food and Drug Administration approved polatuzumab vedotin-piiq with a rituximab product, cyclophosphamide, doxorubicin, and prednisone (R-CHP) for adult patients who have previously untreated diffuse large B-cell lymphoma (DLBCL), not otherwise specified (NOS), or high-grade B-cell lymphoma (HGBL) and who have an International Prognostic Index (IPI) score of 2 or greater.
An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against B-cell antigen receptor complex-associated protein beta chain (CD79B) conjugated, via a protease-cleavable peptide linker, to monomethyl auristatin E (MMAE), an auristatin derivative and a potent microtubule inhibitor, with potential antineoplastic activity. Upon administration, the monoclonal antibody moiety of polatuzumab vedotin-piiq selectively binds to CD79B, a protein which is abundantly expressed on the surface of B-cells. Upon internalization and proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, resulting in G2/M phase arrest and tumor cell apoptosis. CD79B, a component of the B-cell receptor (BCR), plays a key role in B-cell receptor signaling and is expressed on the surface of almost all types of malignant B-cells.
How can 1 go about obtaining polatuzumab vedotin-piiq for injection?
If polatuzumab vedotin-piiq for injection are not yet approved or available in your area, you may request its price in India under a specific brand name through IPN. For assistance and guidance, you can contact us by providing complete details. Our pharmaceutical expert will help you find a suitable and practical solution to your query. To receive comprehensive support, please call us at +91 9891 296 838 (Mr. Tarun) / +91 9811 747 774 (Mr. Neeraj).
POLIVY (polatuzumab vedotin-piiq) for injection, for intravenous use Initial U.S. Approval: 2019
References
- HIGHLIGHTS OF PRESCRIBING INFORMATION
- FDA Approves Polatuzumab Vedotin Plus R-CHP for Previously Untreated DLBCL
- FDA to Review Polatuzumab Vedotin Combo Tx for Previously Untreated DLBCL
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