Jeselhy (pimitespib) inhibits HSP90, thereby showing an antitumor effect by destabilizing and reducing proteins such as KIT, PDGFRA, HER2, and EGFR which are involved in the growth and survival of cancer. It is indicated for the treatment of gastrointestinal stromal tumors (GIST) that have progressed after chemotherapy. Jeselhy has been approved by the PMDA in Japan in June 2022.
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DISEASE INDICATIONS-Gastric Cancer
MEDICINE APPROVED BY-Pharmaceuticals and Medical Devices Agency (PMDA)
Summary of FDA-approved use on approval date: Click Here
(see Drugs@FDA for complete indication)
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Approved accessible "pimitespib tablets"
Pimitespib (trade name Jeselhy) is a drug for the treatment of gastrointestinal stromal tumors. It was discovered and developed by Taiho Pharmaceutical Co. The mechanism of action of pimitespib involves inhibition of heat shock protein 90 (Hsp90). In June 2022, it received approval in Japan for gastrointestinal stromal tumors that have progressed after chemotherapy.
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Jeselhy Tablets 40 mg (Pimitespib)
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