calaspargase pegol -mknl injection
for intravenous use Initial U.S. Approval: 2018
Asparlas (calaspargase pegol-mknl) is a component of a multiagent chemotherapeutic regimen for the treatment of Acute Lymphoblastic Leukemia (ALL) in pediatric and young adult patients aged 1 month to 21 years.
Facts about calaspargase pegol -mknl injection
MEDICINE APPROVED BY-Food and Drug Administration (FDA)
Summary of FDA-approved use on approval date: Click Here
(see Drugs@FDA for complete indication)
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Query For calaspargase pegol-mknl injection
Approved accessible "calaspargase pegol-mknl injection"
Calaspargase pegol, is a medication for the treatment of acute lymphoblastic leukemia (ALL). It is approved in the United States as a component of a multi-agent chemotherapeutic regimen for ALL in pediatric and young adult patients aged one month to 21 years.
Calaspargase pegol is an engineered protein consisting of the E. coli-derived enzyme L-asparaginase II conjugated with succinimidyl carbonate monomethoxypolyethylene glycol (pegol). The L-asparaginase portion hydrolyzes L-asparagine to L-aspartic acid depriving the tumor cell of the L-asparagine it needs for survival. The conjugation with the pegol group increases the half-life of the drug making it longer acting.
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ASPARLAS (calaspargase pegol -mknl) injection, for intravenous use Initial U.S. Approval: 2018
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