ado-trastuzumab emtansine for injection,
for intravenous use Initial U.S. Approval: {YYYY}
Kadcyla (trastuzumab emtansine) is a cancer medicine that is used to treat advanced or metastatic HER2-positive breast cancer (cancer that has spread to other parts of the body) in adults who previously received trastuzumab and a taxane.
Facts about ado-trastuzumab emtansine for injection
Disease Indications-Breast Cancer
Manufacturer-Genentech, Inc
Usage-Intravenous
Medicine Approved By-European Medical Agency (EMA), Food and Drug Administration (FDA), Health Canada, Therapeutic Goods Administration (TGA), Medsafe (NZ)
Summary of FDA-approved use on approval date: Click Here
(see Drugs@FDA for complete indication)
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Query For ado-trastuzumab emtansine for injection
Approved accessible "ado-trastuzumab emtansine for injection"
Ado-Trastuzumab emtansine also known as ado-trastuzumab emtansine and sold under the trade name Kadcyla, is an antibody-drug conjugate consisting of the humanized monoclonal antibody trastuzumab (Herceptin) covalently linked to the cytotoxic agent DM1. Trastuzumab alone stops growth of cancer cells by binding to the HER2 receptor, whereas trastuzumab emtansine undergoes receptor-mediated internalization into cells, is catabolized in lysosomes where DM1-containing catabolites are released and subsequently bind tubulin to cause mitotic arrest and cell death.
How can 1 go about obtaining ado-trastuzumab emtansine for injection?
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KADCYLA (ado-trastuzumab emtansine) for injection, for intravenous use Initial U.S. Approval: {YYYY}
References
- Full prescribing information [FDA]: Kadcyla (trastuzumab emtansine) [PDF], Genentech, May 2019.
- Kadcyla Breastcancer.org
- Australian Product Information [TGA]: Kadcyla (trastuzumab emtansine) [PDF], Roche, Sep 2019.
- U.S. Food and Drug Administration. FDA approves ado-trastuzumab emtansine for early breast cancer. 06/05/2019 (last update: 06/05/2019), cited on 10/03/2020.
- Summary of Product Characteristics [EMA]: Kadcyla (trastuzumab emtansine) [PDF], Roche, Jan 2020.
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