enfortumab vedotin-ejfv for injection
enfortumab vedotin-ejfv for injection
for intravenous use Initial U.S. Approval: 2019
Padcev (enfortumab vedotin-ejfv) is a medication used for the 2nd-line treatment of adults with bladder cancer and cancers of the urinary tract.
Facts about enfortumab vedotin-ejfv for injection
Disease Indications-Urothelial Carcinoma
Manufacturer-Astellas Pharma Inc.
Usage-1.25 mg/kg intravenous infusion
Medicine Approved By-Food and Drug Administration (FDA)
Summary of FDA-approved use on approval date: Click Here
(see Drugs@FDA for complete indication)
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Query For enfortumab vedotin-ejfv for injection
Approved accessible "enfortumab vedotin-ejfv for injection"
Enfortumab vedotin is indicated for the treatment of adults with locally advanced (when cancer has grown too large to be surgically removed) or metastatic (when cancer cells spread to other parts of the body) urothelial cancer who have previously received a programmed death receptor-1 (PD-1) or programmed death ligand 1 (PD-L1) inhibitor and a platinum-containing chemotherapy.
Enfortumab vedotin, is an antibody-drug conjugate used for the treatment of urothelial cancer. It is a nectin-4-directed antibody and microtubule inhibitor conjugate. Enfortumab refers to the monoclonal antibody part, and vedotin refers to the payload drug (MMAE) and the linker. The fully humanized antibody was created by scientists at Agensys (part of Astellas) using Xenomice from Amgen; the linker technology holding the antibody and the toxin together was provided by and licensed from Seattle Genetics. The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication
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Padcev (enfortumab vedotin-ejfv for injection) for intravenous use Initial U.S. Approval: 2019
References
- For Padcev (enfortumab vedotin-ejfv) Indications And Usage, Dosage And Administration, Dosage Forms And Strengths and Drug Interactions For More Details
- Astellas and Seattle Genetics Receive FDA Breakthrough Therapy Designation for PADCEV™ (enfortumab vedotin-ejfv) in Combination with Pembrolizumab in First-Line Advanced Bladder Cancer For More Details
- Enfortumab Vedotin + Pembrolizumab Shrink Tumors in the Majority of Bladder Cancer Patients For More Details
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