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Medicines For Leukemia Treatment
IPN, New Delhi can facilitate Leukemia patient to “import of Medicines For Leukemia Treatment” for personal use under “patient name basis” treatment in India. For this applicant is required to make an request application with required document. IPN, New Delhi will do the necessary process to obtain permission from Drugs Controller General (India) to import.
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There are several types of medicines used in the treatment of leukemia, a type of cancer that affects the blood and bone marrow. The specific medicines used will depend on the type of leukemia, the stage of the disease, and the patient’s overall health. Some common types of medicines used to treat leukemia include: Chemotherapy, Targeted therapy, Immunotherapy, Radiation therapy, Stem cell transplantation, Corticosteroids.
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Chemotherapy is a common treatment for leukemia, a type of cancer that affects the blood and bone marrow. Chemotherapy drugs work by killing rapidly dividing cancer cells throughout the body, including the bone marrow, where leukemia cells are produced. Chemotherapy can be given in several ways, including orally in pill form, through injection into a vein, or directly into the spinal fluid.
The specific chemotherapy drugs used to treat leukemia will depend on the type of leukemia, the stage of the disease, and the patient’s overall health. Some common chemotherapy drugs used to treat leukemia include:
- Cytarabine (Ara-C): This drug is often used to treat acute myeloid leukemia (AML). It works by blocking the production of DNA in leukemia cells, preventing them from dividing and growing.
- Methotrexate: This drug is used to treat acute lymphoblastic leukemia (ALL). It works by interfering with the production of DNA in leukemia cells, causing them to die.
- Vincristine: This drug is also used to treat ALL. It works by disrupting the formation of the microtubules that leukemia cells need to divide and grow.
- Fludarabine: This drug is used to treat chronic lymphocytic leukemia (CLL). It works by interfering with DNA synthesis in leukemia cells, preventing them from dividing and growing.
- Busulfan: This drug is often used in preparation for stem cell transplantation, which is a common treatment for certain types of leukemia. It works by damaging DNA in leukemia cells, preventing them from dividing and growing.
Targeted therapy is a type of cancer treatment that focuses on specific molecules and pathways that contribute to cancer growth and survival. Unlike chemotherapy, which can affect both cancer and healthy cells, targeted therapy is designed to selectively target cancer cells, with fewer side effects.
There are several targeted therapy drugs that are used to treat leukemia, including:
- Imatinib (Gleevec): This drug is used to treat chronic myeloid leukemia (CML) and some types of acute lymphoblastic leukemia (ALL). It targets the abnormal protein produced by the Philadelphia chromosome, which is found in most cases of CML and some cases of ALL.
- Dasatinib (Sprycel): This drug is also used to treat CML and some types of ALL. It targets the same protein as imatinib, but is effective against some imatinib-resistant forms of leukemia.
- Nilotinib (Tasigna): This drug is another targeted therapy for CML that targets the abnormal protein produced by the Philadelphia chromosome.
- Venetoclax (Venclexta): This drug is used to treat some types of chronic lymphocytic leukemia (CLL). It targets a protein called BCL-2, which helps cancer cells survive.
- Midostaurin (Rydapt): This drug is used to treat acute myeloid leukemia (AML) that has a specific genetic mutation called FLT3. It works by inhibiting the activity of the FLT3 protein, which helps leukemia cells grow and divide.
Immunotherapy is a type of cancer treatment that uses a person’s immune system to help fight cancer. There are several immunotherapy drugs that are used to treat leukemia, including:
- Blinatumomab (Blincyto): This drug is used to treat a specific type of acute lymphoblastic leukemia (ALL) that has a genetic abnormality called Philadelphia chromosome-negative. It works by attaching to cancer cells and activating the immune system to destroy them.
- Tisagenlecleucel (Kymriah): This is a type of chimeric antigen receptor (CAR) T-cell therapy that is used to treat B-cell ALL that has not responded to other treatments. It involves modifying a patient’s own T cells in the laboratory so that they can better recognize and attack cancer cells.
- Nivolumab (Opdivo): This drug is used to treat some types of adult T-cell leukemia/lymphoma (ATL), a rare and aggressive type of leukemia. It works by blocking a protein called PD-1, which cancer cells use to evade detection by the immune system.
- Pembrolizumab (Keytruda): This drug is also used to treat some types of ATL. Like nivolumab, it works by blocking PD-1 to help the immune system recognize and attack cancer cells.
- Alemtuzumab (Campath): This drug is used to treat some types of chronic lymphocytic leukemia (CLL). It works by targeting a protein called CD52, which is found on both cancer cells and some healthy immune cells. By depleting these immune cells, the drug can help reduce the number of cancer cells in the body.
Targeted therapy drugs work by targeting specific molecules that are involved in the growth and survival of leukemia cells. These drugs can be given orally or through injection.
The choice of medicines for leukemia treatment will depend on several factors, including the type and stage of the disease, the patient’s age and overall health, and the presence of any other medical conditions. Treatment plans are usually developed by a team of healthcare professionals, including hematologists, oncologists, and other specialists, who will work together to determine the best course of treatment for each individual patient.
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