Getting-to Know about Prostate Cancer and its Newly FDA-Approved Treatment

Prostate cancer is a type of cancer that occurs in the prostate. A prostate is a walnut-sized gland in men that produces the seminal fluid that nourishes and transports sperm. Being the most common type of cancer in men, most of the cases occur in men older than the age of 65. Usually, prostate cancer grows slowly and is initially confined to the prostate gland, where it may not cause serious harm.

You might have got the hint from the topic that today we will be discussing a new type of cancer, known as, Prostate cancer. We will be also discussing the advanced level of prostate cancer and how can you get treated through our prescribed life-saving medicine as it has been approved by the FDA after certain clinical trials.

Prostate Cancer

Above we had a little overview of what the prostate cancer is. The Prostate is a small gland that is found in a man’s lower abdomen. It is located under the bladder and surrounding the urethra. When an abnormal, malignant growth of cells appears in the prostate, it is called to be the occurrence of prostate cancer. There are four stages of prostate cancer:

• Stage I and Stage II: This is the stage where the tumour has been recently diagnosed but has not yet spread beyond the prostate. It is also called “localised prostate cancer”.
• Stage III: This is the stage where cancer has started spreading outside the prostate gland and has affected nearby tissues. It is also known as “locally advanced prostate cancer”
• Stage IV: This is the stage where cancer has started to spread outside the prostate to the other parts such as lymph nodes, bones, liver or lungs. It is also known as “advanced prostate cancer”.

Now let us get to know a little about advanced prostate cancer.

Advanced Prostate Cancer

When prostate cancer starts spreading beyond the prostate gland or makes its appearance once again after the treatment, it is often called advanced prostate cancer.  Cancer at this stage is not “curable”, but it can be controlled through many treatments, through which you will be able to feel better and live longer. Below find out the ways it can get treated:

• Hormone Therapies
• Cancer Vaccines
• Chemotherapy
• Bone Pain Treatment

Also, there are several types of advanced prostate cancer, which can also be treated easily:

• Castration-Resistant Prostate Cancer
• Non-metastatic Castration-Resistant Prostate Cancer
• Metastatic Prostate Cancer
• Metastatic Hormone-Sensitive Prostate Cancer
• Metastatic Castration-Resistant Prostate Cancer
• Metastatic Castration-Sensitive Prostate Cancer

Now, let us get to know how can you verify if you have prostate cancer or not.

Indicators

Men with advanced prostate cancer may or may not have symptoms. Indicators depend on the size of new growth and where the cancer has spread in the body. Check out the following indicators for prostate cancer in advanced stages:

• Trouble or severe pain in urination
• Blood in Semen
• Bone Pain
• Discomfort in the pelvic area
• Erectile dysfunction

Though it can be corrected after the treatment and medications, it would be best if we recommend you to prevent it just be following some of the healthy tips and tricks.

Prevention

As you have heard the phrase, “Prevention is better than Cure”, why don’t implement it in the first phase. It can reduce the risk of prostate cancer through:

• Consuming a healthy diet, full of fruits and vegetables and avoiding high-fat foods
• Consuming healthy foods over supplements
• Maintaining a healthy weight
• Exercising out regularly

Well, now we have discussed quite a lot about prostate cancer. Now, we will be discussing taking the treatment for the specific type of advanced prostate cancer.

Exploring the Life-Saving Medication for Metastatic Castration-Sensitive prostate Cancer: Apalutamide (Erleada)

On September 17, 2019, the U.S. Food and Drug Administration approved Apalutamide for male patients aged above 65 diagnosed with metastatic castration-sensitive prostate cancer. Initially, it was approved in 2018 for patients with non-metastatic castration-resistant prostate cancer.

Apalutamide is an androgen receptor inhibitor that binds directly to the ligand-binding domain of the androgen receptor-mediated transcription. Apalutamide inhibits androgen receptor nuclear translocation, inhibits DNA binding, and impedes androgen receptor-mediated transcription.

Taking the Life-Saving Medication

Apalutamide (Erleada) is an oral drug approved by U.S. Food and Drug Administration for the treatment of patients with metastatic castration-sensitive prostate cancer. The recommended dose of apalutamide is 240 mg once a day and has to be consumed orally. Patients should also receive a gonadotropin-releasing hormone (GnRH) analogue concurrently or have an option of bilateral orchiectomy.

If adverse or severe intolerable symptoms occur, we advise to pause the treatments until symptoms improve to the original grade and can be resumed at the same dose or a reduced dose of 180 mg or 120 mg.

Checking on the Side Effects

Most common adverse reactions that occurred frequently in the patients are:

• Fatigue, Arthralgia, Rashes, Fracture
• Decreased Appetite, Weight, Falls,
• Hypertension, Hot Flush, Diarrhoea

Checking out on Precautions/Warnings

Apalutamide carries following warning that patients and their families have to keep in mind:

• It carries precautions for ischemic cardiovascular events, fractures, falls (mainly in elderly patients), seizures, and embryofoetal toxicity.
• Patients with the risk of fracture and those who have weak bones should be evaluated.
• Patients with active female partners of reproductive potential are advised to use effective contraception.

As we have given you an overall knowledge about how can Metastatic Castration-Sensitive prostate Cancer can be cured with some precautions and life-saving medications, there’s a possibility you might have your doubts about prostate cancer and its treatments cleared. As these drugs received approvals from FDA, these drugs are also being made available in all the countries on emergency basis for the treatment of prostate cancer.

If you want to know about the life-saving treatments, consult the best organisation for knowing about the drug such as ourselves because we will guide you in all the processes, from reaching out the best physicians to making out the arrangements for your treatments.

Get in touch with of best pharmaceutical consultants at Indian Pharma Network as we will assist you with the best advice and any medication that you need from any part of the globe.

Visit: https://indianpharmanetwork.co.in/

Or

Call Mr Neeraj Nagpal on 9811747774

Reference Link:

• https://ascopost.com/issues/november-25-2019/apalutamide-for-metastatic-castration-sensitive-prostate-cancer/
• https://ecancer.org/en/news/16638-fda-approves-apalutamide-for-patients-with-metastatic-castration-sensitive-prostate-cancer
• https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-apalutamide-metastatic-castration-sensitive-prostate-cancer
• https://www.urologyhealth.org/urologic-conditions/advanced-prostate-cancer#Symptoms
• https://www.targetedonc.com/view/fda-approves-apalutamide-for-metastatic-castrationsensitive-prostate-cancer
• https://pubmed.ncbi.nlm.nih.gov/31150574/