FASENRA is an interleukin-5 receptor alpha-directed cytolytic monoclonal antibody (IgG1, kappa) indicated for the add-on maintenance treatment of patients with severe asthma aged 12 years and older, and with an eosinophilic phenotype.
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Benralizumab (trade name Fasenra) is a monoclonal antibody which developed by MedImmune for the treatment of asthma. It is directed against the alpha-chain of the interleukin-5 receptor (CD125). Two Phase 3 clinical trials of benralizumab, SIROCCO and CALIMA, reported meeting their primary endpoints in 2016. It was approved by the US FDA in November 2017 for the treatment of severe eosinophilic asthma.
FASENRA (benralizumab) injection, for subcutaneous use
Generic Name: benralizumab
Injection: 30 mg/mL solution in a single-dose prefilled syringe.
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