Defitelio® (defibrotide sodium) is indicated for the treatment of adult and pediatric patients with hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), with renal or pulmonary dysfunction following hematopoietic stem-cell transplantation (HSCT).
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Defibrotide, sold under the brandname Defitelio, is a mixture of single-stranded oligonucleotides that is purified from the intestinal mucosa of pigs. It is used to treat veno-occlusive disease of the liver of people having had a bone marrow transplant, with different limitations in the US and Europe.
DEFITELIO (defibrotide sodium) injection, for intravenous use Initial U.S. Approval: 2016
Generic Name: defibrotide sodium
Injection: 200 mg/2.5 mL (80 mg/mL) in a single-patient-use vial.
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