AFINITOR is a kinase inhibitor indicated for the treatment of patients with: • advanced renal cell carcinoma (RCC) after failure of treatment with sunitinib or sorafenib. • subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis (TS) who require therapeutic intervention but are not candidates for curative surgical resection. The effectiveness of AFINITOR is based on an analysis of change in SEGA volume. Clinical benefit such as improvement in disease-related symptoms or increase in overall survival has not been demonstrated.
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The order for AFINITOR (everolimus) tablets will be confirmed only after the receipt of valid prescription of doctor and import permit if applicable.
Everolimus is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an inhibitor of mammalian target of rapamycin (mTOR). It is currently used as an immunosuppressant to prevent rejection of organ transplants and in the treatment of renal cell cancer and other tumours. Much research has also been conducted on everolimus and other mTOR inhibitors as targeted therapy for use in a number of cancers.
AFINITOR (everolimus) tablets for oral administration Initial U.S. Approval: 2009
Generic Name: everolimus
2.5 mg, 5 mg, and 10 mg tablets with no score
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For AFINITOR (everolimus) Indications And Usage, Dosage And Administration, Dosage Forms And Strengths and Drug Interactions For More Details
Properties of FDA-approved small molecule protein kinase inhibitors: A 2020 update. For More Details
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